Prednisone, Deltasone, Liquid Pred
BRAND NAME: Deltasone, Orasone, Prednicen-M, Liquid Pred
Prednisone, Deltasone, Liquid Pred
Prednisone is an corticosteroid obtained artificially. It is administrated in order to reduce the reaction of the immune system during an allergic reaction and to ease inflammations.It is similar to active substances contained in the following drugs: Kenacort, Medrol, Prelone and Decadron.
Cortisol is a natural substance, produced in the body, by the suprarenal glands. Cortisol is a corticosteroid, a type of hormone that has a number of effects on the organism. It is most commonly used against inflamations related to the immune system: arthritis, colitis, asthma, bronchitis and other allergies in the eyes and nose area.
Prednisone as such needs to be metabolised by the liver to have the required effect (it is administrated orally) so it may not be effective on people that have liver problems.
Prednisone is a substance generically avaliable with a prescription. It comes in tablets of 2.5 to 50 mg, or syrup. Once aquired, it needs to be stored at room temperature and in conditions of low humidity.
Prednisone is prescribed to alleviate inflammations that occur because of an allergic reaction. It is also used in the treatment of arthritis, ulcerative colitis, Crohn’s disease, systemic lupus, allergic reactions, asthma, severe psoriasis leukemias, lymphomas, idiopathic thrombocytopenic purpura and autoimmune hemolytic anemia.
Corticosteroids reduce the action of the immune system, therefore this group of substances are also administrated to patients that have undergone surgical organ or skin transplants, so the body can accept them and not consider them „foreign infectious factors”.
Also, when the suprarenal glands do not produce enough such hormones, the quantity can be supplemented with prednisone.
The ammount of prednisone administred depends on the type of illness that has to be treated and the patient’s age. The first dose can be small, from 5 mg daily, and it will be adjusted depending on the response. Results are visible after several days, but prednisone must not be administered for a long period of time as the suprarenal glands can stop functioning. When the treatment has to stop, even temporarily, the dose must be reduced gradually, not to affect the suprarenal glands.
INTERACTIONS WITH OTHER SUBSTANCES
An interaction with hormones like estrogen (also a natural steroid, that stimulatse the development of female secondary sex characteristics ) would reduce the capacity of the liver to metabolize prednisone and release the active form prednisolone. Therefore, the side effects would occur more often.
Phenytoin is an anticonvulsant drug used in the management of epilepsy and in the treatment of abnormal heart rhythms. It can reduce the effect of prednisone, therefore, under an existing treatment with phenytoin, the dose of prednisone has to be increased.
Although normally such steroids get from the placenta into the fetus, prednisone has a reduced risk of doing so. Still, intense use of corticosteroids in the first trimester may cause severe malformations such as cleft palate (a congenital crack or fissure in the midline of the hard palate,often associated with a harelip).
Unlike most corticosteroids, prednisone has a low risk of being passed on to the child through breast milk, but it can cause side effects.
SECONDARY REACTIONS: The range of secondary reactions is very wide, and it varies from small nuisances to serious damage. As the doses and period of treatment increase, so do the risks of dangerous side effects: salt retention, weight increase, hypertension, potassium deprivation, cephalgia. Prednisone can also affect wound healing, it can cause face swelling, glaucoma, ulcers, convultions. Also it may cause hormonal irregularities such as facial hair, abnormal menses or even obesity and a number of psychiatric disorders, like insomnia, mood swings, depression, or psychotic behavior.
Prednisone leaves the body more exposed to infections, because it represses the immune system. Also, administrating it on the long term, it may also lead to osteoporosis, therefore, patients have to take calcium and vitamin supplements.
If the prednisone treatment is very long, the suprarenal glands can stop working, and an adrenal crisis may appear, caused by not having enough corticosteroids secreted in the body. This crisis is usually signaled by nausea, vomiting and shock.
A very dangerous side-effect of administring corticosteroids for long periods of time is necrosis of the hip; it can lead to hip replacement surgery. It can also appear in knee joints.