Crohn Disease

Crohn’s disease is a chronic inflammatory disease localized in the wall of the digestive tract and can affect virtually every segment of the esophagus to the anus, but especially the distal portion of the small intestine (terminal ileitis) and colon, characterized by ulcerative inflammatory lesions that can cause complications such as strictures or fistulas.

 

Crohn’s disease is most common in young adults (15-30 years), but it may occur later in life, with equal incidence in men and women.

The cause of Crohn’s disease is not known.

genetics, infections, imune disorders are possible variations but none has been clearly demonstrated.

The severity of diarrhea and inflammatory stomach disorders may require emergency hospitalization, sometimes the symptoms can seam as acute appendicitis or intestinal obstruction, but often, patients are hospitalized to determine the cause of prolonged diarrhea or fever syndrome or scared of bleeding peristent rectum.

The most common Crohn’s disease is a chronic evolution and relapse attenuation, with remission lasting weeks, months or years, interspersed by severe exacerbations.

Positive diagnosis is suggested by the symptoms mentioned, helped by the analysis of this biological inflammatory syndrome (elevated ESR, fibrinogen, C-reactive protein), possibly anemia and digestive endoscopy confirmed (diffuse involvement, discontinuous mucosa with deep ulceration and linear, with highlighting the inflammatory histopathology in biopsy fragments taken). Barium radiological examination of the digestive tract may be useful in assessing the existence and extent of disease complications (fistulas). Exploration of modern imaging (CT, MRI) can help also, in diagnosing complications of Crohn’s disease (abscesses, fistulas).

It turned out that the disease may be triggered by the appearance of an abnormal immune response against intestinal bacteria saprophytic.

 

 

Symptoms of Crohn’s disease include:

– Chronic and repeated abdominal ache. Abdomen of patients with Crohn’s disease may be sensitive to palpation;

– Diarrhea

– Loss of appetite;

– Weight loss.

– Anemia

– Fistulas (lesions of the intestinal wall, with the formation of abnormal tracks between bowel and adjacent organs).

– Intestinal abscess

– Anal fissures

Crohn’s disease with persistent symptoms, require administration of medications. These drugs are very effective in most cases of Crohn’s disease, especially those with intestinal lesions present in the colon and ileocaecal area (the area that connects the small intestine and thick).It is not recommended, however, that these drugs should be administered for a long time (months, years), because they have undesirable side effects (hypertension, osteoporosis, infection, infertility, diabetes mellitus).

Complications of Crohn’s disease and intestinal fistulae (abnormal formation of tracks between a segment of intestine and another or between the intestine and a neighboring organ), require antibiotics to prevent serious infections at this level.

The worst forms of Crohn’s disease with severe symptoms and complications require taking immunosuppressive drugs (which inhibit the immune system). Treatment of this disease aims to prevent overheating and to maintain as long periods of remission. Some patients have more serious symptoms and require complementary therapies such as surgery. Crohn’s disease therapy is done correctly according to the type and severity of disease.

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